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Download free pdf of Principles Of Biostatistics, Second EditionMonitoring of CD14 +CD16+ monocytes and MMP-9 in patients with early stages of rheumatoid arthritis.
Inflammatory mediators are involved in the pathogenesis and progression of rheumatoid arthritis (RA). CD14+CD16+ monocytes are relevant for the immune response in RA, and MMP-9 is a reliable marker of chronic inflammation. The aim of this study was to compare these cell subpopulations and MMP-9 in patients with early stages of RA with healthy controls, and to evaluate their potential as biomarkers for RA. Twelve patients with early RA and eleven healthy controls underwent a complete blood cell analysis with flow cytometry. Peripheral blood CD14+CD16+ monocytes were examined for their percentage, as well as MMP-9 production and surface expression. Monocytes were defined as CD14+CD16+ cells and CD14+ cells in flow cytometry, respectively. The percentage of CD14+CD16+ monocytes was higher in RA patients than in healthy controls (4.7 +/- 1.8% vs. 3.3 +/- 0.9%, p Social Justice and Philosophy for the Young

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