AAct Network 1.0.1 Portable VERIFIED

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AAct Network 1.0.1 Portable

Among patients who received treatment with sarilumab, a trend toward reduced mortality at 28 days was observed compared to usual care (network estimate OR: 0.81; 95% CI: 0.60, 1.10; low certainty of evidence). Sarilumab may reduce clinical deterioration, defined as progression to intubation, ECMO or death compared to usual care (RR: 0.72; 95% CI: 0.44, 1.18; very low CoE).

Among hospitalized patients who received treatment with sarilumab, a trend toward reduced mortality at 28 days was observed compared to usual care (network estimate OR: 0.81; 95% CI: 0.62, 1.05; low certainty of evidence). Sarilumab may reduce clinical deterioration, defined as progression to intubation, ECMO or death compared to usual care (RR: 0.73; 95% CI: 0.47, 1.14; very low CoE).

Conditions:
A dual BIG-IP configuration may provisioned with the following considerations.

— One or more BIG-IP systems are in the network path for monitor traffic.

— The first BIG-IP system uses a health monitor that initiates a health check request (without an HTTP version) in the request line (HTTP/0.9) against a second BIG-IP system.

— The second (downstream) BIG-IP system has a virtual server that is the endpoint for the monitor. The virtual server is configured with an HTTP profile with the HTTP RFC Compliance profile option selected.

Among patients who received treatment with tocilizumab, a trend toward reduced mortality at 28 days was observed compared to usual care (network estimate OR: 0.92; 95% CI: 0.73, 1.17; low certainty of evidence). No significant difference was observed in the primary outcome, defined as ICU admission, mechanical ventilation or death at 28 days (RR: 0.90; 95% CI: 0.75, 1.09; very low CoE).

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