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; Samsung Z3x Box Slim Z3X 4GB GPRS External Device. Each box can be set to print or open the box itself. Samsung Z3x Box Slim Z3X 4GB GPRS External Device. Each box can be set to print or open the box itselfCD6
CD6 is a cell surface molecule and the human homologue of rat CD5. CD6 is one of the three co-stimulatory molecules that are expressed on T cells and interacting with other coreceptors CD7, CD28, and CD95. CD6 interacts with the cytoplasmic domain of the T cell receptor. CD6 also has a potential role in T cell signaling.
Effects
CD6, in conjunction with other coreceptors, can modulate the T cell response. CD6 ligation results in the calcium flux (in T-helper cells) and the activation of multiple signaling molecules, including the protein tyrosine kinases ZAP-70 and Syk, and the adapter molecule SLP-76. CD6-deficient mice have a reduced number of peripheral T cells and a failure of T-cell homeostasis in spleen and thymus. As such, CD6 plays a role in the development of T cells. CD6 is expressed on thymocytes and all mature T cells.
T cell activation
The mechanism by which CD6 enhances T cell activation is still unknown. CD6 is part of the coreceptor complex for T cell activation. The coreceptor CD28 enhances T cell proliferation and cytokine production via interactions with CD80/CD86, whereas CD6 binds to a different region of CD28 than CD80/CD86. CD6 and CD28 are expressed on activated T cells (e.g., after interaction with antigen-presenting cells), but CD6 can be also be expressed on resting T cells, as well as CD4 and CD8-deficient T cells.
In addition to its role in T cell activation, CD6 binds to the coreceptor CD72 on APC, which promotes the maturation and activation of B cells. CD72 is expressed on the surface of activated dendritic cells, and its expression is reduced following maturation or deactivation of dendritic cells. CD72 is also expressed by B cells at all stages of B cell development. CD72 is expressed by human B cells during terminal differentiation to plasma cells.
Coreceptor
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