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USB Fix Free Download For Window.UsbFix 32bit. UsbFix is a free, malware removal program that helps you to find and delete. usbfix Download]. In parallel to these in vitro findings, previous reports have demonstrated that intravenous administration of exosomes secreted from stem cells did not result in a shortening of MCAO-induced cerebral infarcts \[[@B26]-[@B29]\]. However, one study has shown the transient clinical improvement following intravenous administration of stem cell-derived exosomes \[[@B30]\]. We have previously shown that treatment with intravenous exosomes secreted from MSCs attenuated cerebral infarcts and neurological deficits in MCAO rats via the activation of autophagy \[[@B9]\]. In the present study, we have demonstrated that treatment with intra-arterial exosomes secreting from MSCs prevented cerebral infarcts and attenuated neurological deficits in MCAO rats. To the best of our knowledge, this is the first report showing the neuroprotective effect of intra-arterial exosomes. Accumulating evidence indicates that autophagy is required for the survival and therapeutic properties of stem cells \[[@B31],[@B32]\]. Accumulating evidence also suggests that microvesicles, like exosomes, can be transported from one cell to another, directly or via the bloodstream \[[@B33]\], and therefore, microvesicles containing stem cell-derived molecules may be therapeutically beneficial \[[@B34]\]. We have previously shown that intra-arterial delivery of exosomes secreted from MSCs activated autophagy and attenuated cerebral infarcts in MCAO rats \[[@B9]\]. In parallel, intra-arterial administration of exosomes secreted from MSCs not only attenuated neurological deficits, but also improved their cardiac function in MCAO rats \[[@B35]\]. We have also previously reported that exosomes secreted from stem cells inhibited the expression of ICAM-1 in activated endothelial cells \[[@B36]\]. In the present study, we have demonstrated that intra-arterial administration of exosomes released from stem cells not only attenuated a cerebral infarct, but also significantly decreased the expression of ICAM-1 in the is a2fa7ad3d0

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