Ahmed Colic Zbirka Zadataka Iz Fizike Za 1 Razred Gimnazije.24 🤙


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Ahmed Colic Zbirka Zadataka Iz Fizike Za 1 Razred Gimnazije.24

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Check out search results for ahmed colic zbirka zadataka iz fizike za 1 razred gimnazije PDF including same page PDF, PDF author page, PDF metadata, PDF description PDF…Investigation of the role of cytochrome P450 enzymes in the metabolism of a new oral potassium sparing agent, levosimendan, in healthy volunteers.
Levosimendan is an effective and safe inotropic drug and its pharmacokinetic characteristics (e.g., absorption, distribution, metabolism and excretion) have been examined in humans. Additionally, there is a need for a more thorough understanding of its metabolism, as reflected by its poor oral bioavailability in humans, which requires enhanced oral exposure for optimal therapeutic effectiveness. Levosimendan undergoes primary hepatic metabolism to form its predominant glucuronide metabolite, M4. The aim of the present study was to examine the role of two cytochrome P450 enzymes, CYP2C19 and CYP3A4 in the metabolism of levosimendan in vitro. Metabolic stability of levosimendan was assessed using human liver microsomes (HLMs) in comparison with recombinant cytochrome P450 enzymes CYP2C19 (including its genetic polymorphisms), and CYP

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