To God be the glory,» an emotional Francis added. 0.80) infection models. The fAUC/MIC targets required to achieve stasis and 1 log kill in opposition to the three strains had been 1.89-7.41 and 6.98-13.6 within the thigh infection model, respectively, whereas the corresponding values were 1.57-6.Fifty two and 8.18-42.1 in the lung infection model. Conclusions: This examine indicates the importance of attaining adequate time-averaged exposure to colistin and outlined goal fAUC/MIC values for various magnitudes of kill. Amplification of resistant subpopulations indicates the importance of investigating rational combos with colistin. Amplification of colistin-resistant subpopulations was revealed for all strains in each models after 24 h colistin treatment. Strategies: PK/PD of colistin was studied in thigh and lung infection fashions in opposition to A. baumannii ATCC 19606 and two multidrug-resistant clinical isolates (two of the three strains had been colistin heteroresistant). Aims: To elucidate the pharmacokinetic/pharmacodynamic (PK/PD) index that predicts colistin efficacy against Acinetobacter baumannii in neutropenic murine thigh and lung infection models, and to determine the extent of the emergence of resistance in vivo to colistin.

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