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Category:Articles containing video clipsLaser Interstitial Therapy in the Treatment of Men With Low-risk Prostate Cancer: Long-term Results of the LAPPROTECT Study.
To present the long-term results of a prospective randomized trial examining the efficacy and safety of low-dose laser interstitial therapy (LD-LILT) in the treatment of low-risk prostate cancer and to provide data on the recovery of erectile function (EF). A total of 95 men diagnosed with low-risk prostate cancer and initially presenting with a maximum tumor diameter less than 3.5 cm were randomized to treatment with LD-LILT in 1 case. Outcome measures were survival and time to recurrence, metastasis, and progression, as well as the onset of prostate-specific antigen (PSA), PSA kinetics, and EF. Of the 95 men in the study, 96% were treated. The median follow-up time was 96 months (range: 46-159). During that time, 13 (13%) patients had biochemical relapse, 2 (2%) men had distant metastases, and 1 had local progression. Recurrence-free survival was 85%, and 84.8% of men were still living. After 6 months of follow-up, PSA was undetectable in 62.8% of the patients, and after 12 months, it was detectable in 100%. As for oncologic and EF outcome measures, LD-LILT was comparable to surgical approaches. ED developed in 16.3% of the patients, and the recovery of EF began on average in 15 months. LD-LILT allows a high degree of PSA control in patients with low-risk prostate cancer. As a conservative treatment, LD-LILT does not affect EF recovery, although it is associated with a high rate of minor side effects.Flere danske myndigheder vedtager nu en tilladelse til at bruge penge på noget helt andet.

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Take back control of your PC by hiding all critical system functions in a clean overlay that makes them easier to access when you need them.APPLICANT’S DESCRIPTION: We propose to study the structure and function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in the human intestine. CFTR, a member of the ATP-binding cassette (ABC) transporter superfamily, is located at the apical membrane of secretory epithelial cells, and is strongly expressed in the intestine. CFTR has been suggested to be a major player in the chloride secretory pathway of the intestine. CFTR protein abundance is regulated by the molecular chaperone HscA, which is encoded by hscA, an hsp70 heat shock gene located on human chromosome 3p21.3. We have identified the promoter region of hscA and shown that hscA gene regulation is epigenetically mediated. Epigenetic regulation of the hscA gene expression plays a central role in intestinal development and ion transport across the intestinal epithelium. The physiologic importance of hscA gene regulation is demonstrated by the fact that mutations in hscA or in the promoter are responsible for about 10% of the cases of cystic fibrosis (CF) in humans, which is a common lethal autosomal recessive disease of the lung and intestine. The hypothesis that the CFTR protein is involved in human intestinal ion transport is supported by the identification of new disease-causing mutations in the CFTR protein. The specific aims are: 1. To identify the transcriptional regulatory elements in the hscA promoter and in the CFTR gene; 2. To identify the proteins that bind to the hscA regulatory elements and CFTR promoter; 3. To determine whether hscA and CFTR proteins are expressed in the intestine; 4. To test the hypothesis that transcriptional regulation of the hscA gene is mediated by epigenetic mechanisms. 5. To test the hypothesis that CFTR is an intestinal anion channel. The experiments are designed to identify novel regulatory elements in the CFTR

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